Zyban is a prescription medication designed to help smokers quit more easily than without the drug. It comes in a pill form. It does not contain nicotine

What is Zyban? ZybanŽ and WellbutrinŽ are both brand names for the generic drug, bupropion hydrochloride. While bupropion is not for everyone, it does have the advantage of lessening the discomforts associated with nicotine withdrawal. This can make cessation much more manageable for those people who haven't been able to successfully quit smoking using other methods.